Etravirine in combination with darunavir/ritonavir and optimized background regimen results in suppression of HIV replication in treatment-experienced patients. Evaluation of Katlama C, Haubrich R, Lalezari J, et al. Efficacy and safety of etravirine in treatment-experienced HIV-1 patients: pooled 48-week analysis of two randomized, controlled trials. AIDS 2009; 23: 2289-300.

Abstract

Therapeutic options for treatment-experienced HIV-infected patients have been limited. The DUET trial evaluated the use of etravirine, a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), or placebo, in 1203 treatment-experienced, HIV-infected patients. Eligible patients had to have evidence of NNRTI and protease inhibitor resistance-associated mutations, and evidence of virologic failure, as defined as a plasma viral load > 5000 copies/ml on antiretroviral therapy at the time of screening. Patients in both arms received an optimized background regimen including darunavir/ritonavir. DUET demonstrated superior outcomes in virologic suppression (plasma viral load < 50 copies/ml) and clinical end points including new AIDS-defining illnesses and death, in those randomized to receive etravirine. These results were maintained at 48 weeks of follow-up. Furthermore, etravirine was shown to be safe and well-tolerated over this period. In exploratory analyses, patients in the DUET study with greater number of active agents within the background regimen were more likely to have a fully suppressive response. Taken together, the DUET results highlight the high rates of virological success that can be achieved using new active agents, such as ritonavir-boosted darunavir and etravirine, in treatment-experienced patients with underlying drug-resistant HIV infection.

• Authors: Mark W Hull, Julio S G Montaner
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 11 Issue 8 Pg. 1433-7 (Jun 2010) ISSN: 1744-7666 [Electronic] England
• PMID: 20367279 (Publication Type: Journal Article)

Chemical References

• HIV Protease Inhibitors
• Nitriles
• Pyridazines
• Pyrimidines
• Sulfonamides
• etravirine
• Ritonavir
• Darunavir

Topics

• Antiretroviral Therapy, Highly Active (methods)
• Darunavir
• Drug Resistance, Multiple, Viral (drug effects)
• Drug Therapy, Combination
• HIV Infections (drug therapy)
• HIV Protease Inhibitors (therapeutic use)
• HIV-1 (drug effects)
• Humans
• Nitriles
• Pyridazines (therapeutic use)
• Pyrimidines
• Randomized Controlled Trials as Topic
• Ritonavir (therapeutic use)
• Sulfonamides (therapeutic use)
• Viral Load (drug effects)