Abstract | IMPORTANCE OF THE FIELD: AREAS COVERED IN THIS REVIEW: In this review, we introduce the roles of UTI in experimental endotoxin ( lipopolysaccharide; LPS)-related inflammatory disorders using UTI-deficient (-/-) and corresponding wild-type mice. WHAT THE READER WILL GAIN: Our experiments using genetic approach suggest that endogenous UTI can protect against the systemic inflammatory response and subsequent organ injury induced by LPS, at least partly, through the inhibition of pro-inflammatory cytokine and chemokine expression, which provide important in vivo evidence and understanding about a protective role of UTI in inflammatory conditions. TAKE HOME MESSAGE: Using genetically targeted mice selectively lacking UTI, UTI has been evidenced to provide an attractive 'rescue' therapeutic option for endotoxin-related inflammatory disorders such as DIC, acute lung injury and acute liver injury.
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Authors | Ken-ichiro Inoue, Hirohisa Takano |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 19
Issue 4
Pg. 513-20
(Apr 2010)
ISSN: 1744-7658 [Electronic] England |
PMID | 20367192
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Endotoxins
- Glycoproteins
- Inflammation Mediators
- urinastatin
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Topics |
- Acute Lung Injury
(drug therapy, enzymology, pathology)
- Amino Acid Sequence
- Animals
- Disease Models, Animal
- Endotoxins
(adverse effects, toxicity)
- Glycoproteins
(deficiency, physiology, therapeutic use)
- Humans
- Inflammation Mediators
(adverse effects, therapeutic use, toxicity)
- Liver Failure, Acute
(drug therapy, enzymology, pathology)
- Mice
- Mice, Knockout
- Mice, Transgenic
- Molecular Sequence Data
- Shock, Septic
(drug therapy, enzymology, pathology)
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