Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC.
Abstract | BACKGROUND: METHODS: RESULTS: The positive expression of VEGF-C and VEGF were detected in 54 (48.7%) and 86 (73.5%), respectively. We identified micrometastatic tumor cells in pathological N0 LNs in 34 (29.1%) of 117 patients. E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin were identified in 70 (59.8%), 41 (35.0%), 83 (70.9%), and 61 (52.1%) specimens, respectively. The VEGF-C expression was found more frequently in squamous cell carcinoma (SQ) and in the tumors with negative expression of beta-catenin than counter features. The VEGF expression was found more frequently in the tumors with a negative expression of E-cadherin. Micrometastasis was found more frequently in a pathological T2 status and in the tumors with a negative expression of alpha-catenin. Beta-catenin and gamma-catenin expressions were found less and more frequently in SQ, respectively. A univariate and multivariate survival analysis demonstrated that old age, pathological T2 status, and micrometastasis were independently associated with an increased risk of poor survival in the patients who underwent a surgical resection of stage I NSCLC. CONCLUSIONS: Complicated relationships exist between lymphangiogenesis/ micrometastases and adhesion molecules with a specific histology. The detection of lymph nodal micrometastasis by CK may therefore be a useful marker for predicting a poor prognosis in patients who undergo a complete resection of stage I NSCLC.
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Authors | Toshihiro Yamashita, Hidetaka Uramoto, Takamitsu Onitsuka, Kenji Ono, Tetsuro Baba, Tetsuya So, Tomoko So, Mitsuhiro Takenoyama, Takeshi Hanagiri, Tsunehiro Oyama, Kosei Yasumoto |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 70
Issue 3
Pg. 320-8
(Dec 2010)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 20363046
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Cadherins
- Catenins
- Vascular Endothelial Growth Factors
- Keratins
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Cadherins
(genetics, metabolism)
- Carcinoma, Non-Small-Cell Lung
(genetics, metabolism, pathology, physiopathology, surgery)
- Catenins
(genetics, metabolism)
- Cell Adhesion
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Keratins
(genetics, metabolism)
- Lung Neoplasms
(genetics, metabolism, pathology, physiopathology, surgery)
- Lymph Nodes
(metabolism, pathology)
- Lymphangiogenesis
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Vascular Endothelial Growth Factors
(genetics, metabolism)
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