METHODS: RESULTS: Analyzing Spearman's rank correlation coefficient in a group of affected patients, we noticed a slightly positive correlation of lupus
anticoagulants (LAC) with aCL
antibodies of both classes, while the correlation with b2GP1
IgG was negative. Both classes of aCL
antibodies and anti-b2GP1
IgG were in a discrete positive correlation with the given variables. In the control group, there was a lack of consistency in correlation of the study variables with LAC-aCl
IgG, compared to the affected patients, and there was a standard negative coefficient of correlation with anti-b2GP1
IgG. The correlation ratio of anti-b2GP1
IgG was negative for all studied test parameters. Analysis of
hemostatic parameters showed a statistically significant difference in the concentration of
fibrinogen (p < 0.01) and thrombocyte count (p < 0.05) between the study and the control group of pregnant women. Lower mean values of
fibrinogen (2.90 +/- 0.45 g/L) and lower thrombocyte count [(179.20 +/- 6.00) x 10(9)] were found in the study group of pregnant women with secondary
infertility compared to the mean values of
fibrinogen (3.60 +/- 0.55 g/L) and thrombocyte count [(236.05 +/- 5.10) x 10(9)] in the control group. Activated partial thromboplastin time and prothrombin time were statistically significantly prolonged (p < 0.05) in pregnant women with
spontaneous abortions compared to controls, suggest
anticoagulant activity.
CONCLUSION: