Antitumor activity of methylan polysaccharide derivatives.

Abstract

Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mug ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.

• Authors: Priyadharshini Ramachandran, Marimuthu Jeya, Hee-Jung Moon, Kyoung-Mi Lee, In-Won Kim, Jung-Hoe Kim, Jung-Kul Lee
• Journal: Biotechnology letters (Biotechnol Lett) Vol. 32 Issue 7 Pg. 891-5 (Jul 2010) ISSN: 1573-6776 [Electronic] Netherlands
• PMID: 20349111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Polysaccharides

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Humans
• Molecular Structure
• Polysaccharides (chemistry, pharmacology)
• Structure-Activity Relationship