Abstract | BACKGROUND: METHODS: We reviewed all literature reporting the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. We used a standardized abstraction and grading format and performed meta-analyses to determine the effect of treatment with these antibiotics on rates of treatment failure, bacteriological failure and bacteriological relapse. The CHERG Standard Rules were applied to determine the final effect of treatment with these antibiotics on diarrhoea mortality. RESULTS: Eight papers were selected for abstraction. Treatment with ciprofloxacin, ceftriaxone or pivmecillinam resulted in a cure rate of >99% while assessing clinical failure, bacteriological failure and bacteriological relapse. CONCLUSIONS:
|
Authors | Beatrix S Traa, Christa L Fischer Walker, Melinda Munos, Robert E Black |
Journal | International journal of epidemiology
(Int J Epidemiol)
Vol. 39 Suppl 1
Pg. i70-4
(Apr 2010)
ISSN: 1464-3685 [Electronic] England |
PMID | 20348130
(Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Anti-Bacterial Agents
- Amdinocillin Pivoxil
- Ciprofloxacin
- Ceftriaxone
|
Topics |
- Amdinocillin Pivoxil
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Ceftriaxone
(therapeutic use)
- Child, Preschool
- Ciprofloxacin
(therapeutic use)
- Dysentery
(drug therapy, mortality)
- Dysentery, Bacillary
(drug therapy, mortality)
- Female
- Humans
- Infant
- Male
- Randomized Controlled Trials as Topic
- Salmonella Infections
(drug therapy, mortality)
- Shigella dysenteriae
- Treatment Outcome
|