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Genetics of atrial fibrillation.

Abstract
Recent studies of atrial fibrillation (AF) have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.
AuthorsSteven A Lubitz, B Alexander Yi, Patrick T Ellinor
JournalHeart failure clinics (Heart Fail Clin) Vol. 6 Issue 2 Pg. 239-47 (Apr 2010) ISSN: 1551-7136 [Print] United States
PMID20347792 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright (c) 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Ion Channels
  • KCNE2 protein, human
  • KCNQ1 Potassium Channel
  • KCNQ1 protein, human
  • Potassium Channels, Voltage-Gated
Topics
  • Arrhythmias, Cardiac (genetics)
  • Atrial Fibrillation (epidemiology, genetics)
  • Genome-Wide Association Study
  • Humans
  • Ion Channels (genetics)
  • KCNQ1 Potassium Channel (genetics)
  • Mutation
  • Potassium Channels, Voltage-Gated (genetics)
  • Risk Factors
  • United States (epidemiology)

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