Abstract |
Recent studies of atrial fibrillation (AF) have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.
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Authors | Steven A Lubitz, B Alexander Yi, Patrick T Ellinor |
Journal | Heart failure clinics
(Heart Fail Clin)
Vol. 6
Issue 2
Pg. 239-47
(Apr 2010)
ISSN: 1551-7136 [Print] United States |
PMID | 20347792
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Ion Channels
- KCNE2 protein, human
- KCNQ1 Potassium Channel
- KCNQ1 protein, human
- Potassium Channels, Voltage-Gated
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Topics |
- Arrhythmias, Cardiac
(genetics)
- Atrial Fibrillation
(epidemiology, genetics)
- Genome-Wide Association Study
- Humans
- Ion Channels
(genetics)
- KCNQ1 Potassium Channel
(genetics)
- Mutation
- Potassium Channels, Voltage-Gated
(genetics)
- Risk Factors
- United States
(epidemiology)
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