Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases.

Abstract

Eight hydroxyl-substituted Schiff bases with the different number and position of hydroxyl group on the two asymmetric aromatic rings (A and B rings) were prepared by the reaction between the corresponding aromatic aldehyde and aniline. Their antioxidant effects against the stable galvinoxyl radical (GO(.)) in ethyl acetate and methanol, and 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH)-induced DNA strand breakage, and their antiproliferative effects on human hepatoma HepG2 cells, were investigated. Structure-activity relationship analysis demonstrates that o-dihydroxyl groups on the aromatic A ring and 4-hydroxyl group attached to the aromatic B ring contribute critically to the antioxidant and antiproliferative activities.

• Authors: Li-Xia Cheng, Jiang-Jiang Tang, Hui Luo, Xiao-Ling Jin, Fang Dai, Jie Yang, Yi-Ping Qian, Xiu-Zhuang Li, Bo Zhou
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 8 Pg. 2417-20 (Apr 15 2010) ISSN: 1464-3405 [Electronic] England
• PMID: 20346660 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antioxidants
• Schiff Bases

Topics

• Antioxidants (pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• DNA Damage
• Electrophoresis, Agar Gel
• Humans
• Schiff Bases (pharmacology)
• Spectrophotometry, Ultraviolet
• Structure-Activity Relationship