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High Levels of beta-D-glucan in immunocompromised children with proven invasive fungal disease.

Abstract
The plasmatic levels of 1,3-beta-d-glucan (BDG) were >523 pg/ml in 4 children, 2 low-birth-weight neonates and 2 stem cell transplant recipients, with the following invasive fungal diseases (IFD) proven apart from this BDG test: 3 cases of Candida parapsilosis candidemias and 1 case of disseminated aspergillosis. The BDG test may be useful for identification of IFD in pediatrics.
AuthorsAlessandra Mularoni, Elisa Furfaro, Maura Faraci, Alessia Franceschi, Paola Mezzano, Roberto Bandettini, Claudio Viscoli, Elio Castagnola
JournalClinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 17 Issue 5 Pg. 882-3 (May 2010) ISSN: 1556-679X [Electronic] United States
PMID20335432 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Proteoglycans
  • beta-Glucans
  • polysaccharide-K
Topics
  • Aspergillosis (microbiology, pathology)
  • Aspergillus (isolation & purification)
  • Candida (isolation & purification)
  • Candidiasis (microbiology, pathology)
  • Child
  • Female
  • Fungemia (pathology)
  • Humans
  • Immunocompromised Host
  • Infant, Newborn
  • Male
  • Proteoglycans
  • beta-Glucans (blood)

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