[Preliminary study of XELOX regimen as the first-line chemotherapy in advanced or recurrent gastric cancer].

Abstract

OBJECTIVE:

To evaluate the efficacy and toxicity of the combined therapy with oxaliplatin and capecitabine (XELOX) in patients with advanced or recurrent gastric cancer.

METHODS:

Forty-one patients with previously untreated advanced or recurrent gastric cancer received intravenous infusion of oxaliplatin at the dose of 130 mg/m(2) on day 1 and oral administration of capecitabine at 1000 mg/m(2) twice a day on days 1-14. The chemotherapy was repeated every 2 weeks for a median of 4 cycles.

RESULTS:

Two of 41 patients achieved a complete response, and 15 had partial responses, with an overall response rate of 41.5%. Stable disease was observed in 11 patients and progressive disease in 9. The median time to progression and overall survival was 6.2 months and 11.8 months. All the 41 patients were evaluated for toxicity according to NCI criteria, 4 showed grade 3-4 neural toxicity, 4 had hematological toxicity and 3 had hand-foot syndrome.

CONCLUSION:

The XELOX regimen shows good efficacy with an acceptable toxicity profile in advanced or recurrent gastric cancer patient.

• Authors: Na Min, Ben-fu He, Luo-sheng Zhang, Hong Liao, Yan-zheng Jia
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 30 Issue 3 Pg. 599-601 (Mar 2010) ISSN: 1673-4254 [Print] China
• PMID: 20335149 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Oxaloacetates
• Deoxycytidine
• Capecitabine
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Capecitabine
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Female
• Fluorouracil (analogs & derivatives, therapeutic use)
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy)
• Oxaloacetates
• Stomach Neoplasms (drug therapy, pathology)