Abstract | OBJECTIVE: MATERIAL AND METHODS: A two-center retrospective cohort study was completed. Patients with acute appendicitis (n = 725) were divided into two groups, group A with perforation (n = 155) and group B without (n = 570). RESULTS: In group A an elevated CRP (> 5 mg/l) was measured in 98% of cases versus 72.5% in group B. Hyperbilirubinemia (> 20 micromol/l) was measured in 38% of cases in group A versus 22.3% in group B. Leukocytosis (> 10 x 10(9)/l) was measured in 85% of cases in group A versus 79.3% in group B. Analysis of qualitative and quantitative data showed every marker to be significantly correlated with perforation except elevated white cell blood count. However CRP showed the strongest correlation. The logistic regression model showed CRP to be by far the most significant marker of perforation. CONCLUSIONS:
|
Authors | Samuel Andreas Käser, Gerhard Fankhauser, Niels Willi, Christoph Andreas Maurer |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 45
Issue 7-8
Pg. 885-92
(Aug 2010)
ISSN: 1502-7708 [Electronic] England |
PMID | 20334601
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Biomarkers
- C-Reactive Protein
- Bilirubin
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Appendicitis
(blood, diagnosis)
- Bilirubin
(blood)
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Child
- Cohort Studies
- Female
- Humans
- Leukocytes
- Male
- Middle Aged
- Retrospective Studies
|