High dose calcitriol in osteopetrorickets.

Abstract

Osteopetrorickets is a rare autosomal recessive disorder of osteoclast function characterized by abnormally dense bone and failure of resorption of calcified cartilage. Rickets is a paradoxical complication of osteopetrosis, resulting from the inability of the osteoclasts to maintain a normal calcium-phosphorus balance in the extracellular fluid. We report a patient with an unusual case of infantile osteopetro-rickets who was admitted with anterior fontanel bulging and was treated with haploidentical bone marrow transplantation.

• Authors: A Avni Atay, A Emin Kurekci, Fatih Mehmet Azik, Mustafa Gulgun, Tolga Yavuz, Okan Ozcan
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 22 Issue 12 Pg. 1179-83 (Dec 2009) ISSN: 0334-018X [Print] Germany
• PMID: 20333880 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bone Density Conservation Agents
• Calcitriol

Topics

• Bone Density Conservation Agents (administration & dosage)
• Bone Marrow Transplantation
• Calcitriol (administration & dosage)
• Combined Modality Therapy
• Dose-Response Relationship, Drug
• Female
• Humans
• Infant
• Osteopetrosis (diagnostic imaging, drug therapy)
• Radiography
• Rickets (diagnostic imaging, drug therapy)