(-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells.

Abstract

Sera from chickens that consumed a known level of (-)-gossypol (-)-GP) exhibited bioactivity against human breast cancer cells in vitro. Based on this, it is conceivable that similar anti-breast cancer activities of different magnitudes will be exhibited in biological samples harvested from (-)-GP-fed layer hens. The experimental data generated in this study may influence the fundamental thinking regarding the utilization of low cost agricultural commodities such as (-)-GP cottonseed meal to produce value-added chemopreventive animal products.

• Authors: J M Reddish, W Ye, Y C Lin, M Wick
• Journal: Anticancer research (Anticancer Res) Vol. 30 Issue 2 Pg. 439-44 (Feb 2010) ISSN: 1791-7530 [Electronic] Greece
• PMID: 20332451 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contraceptive Agents, Male
• Cottonseed Oil
• L-Lactate Dehydrogenase
• Myosins
• Gossypol

Topics

• Animal Feed
• Animal Nutritional Physiological Phenomena
• Animals
• Breast Neoplasms (blood, drug therapy, pathology)
• Cell Proliferation (drug effects)
• Chickens (blood, growth & development)
• Contraceptive Agents, Male (pharmacology)
• Cottonseed Oil (pharmacology)
• Female
• Gossypol (pharmacology)
• Humans
• L-Lactate Dehydrogenase
• Liver Function Tests
• Myosins (metabolism)
• Tumor Cells, Cultured