Abstract | OBJECTIVE: STUDY DESIGN: Historical cohort study. SETTING: Otolaryngology department in a university hospital. SUBJECTS AND METHODS: The immunohistochemical expression of bax, cytochrome c, and caspase-8 were studied in paraffin-embedded tissue specimens originating from 27 surgically treated parotid cancer patients and nine patients with Warthin parotid tumors (control group) and correlated with the patients' clinicopathological characteristics and clinical outcome. RESULTS:
Caspase-8 negative staining was more frequently observed in higher TNM stages and in tumors measuring more than 4 cm (P = 0.009 and P = 0.018, respectively). Caspase-8 (-)/ cytochrome c (-) patients carried low-grade lesions without nodal involvement (P = 0.01 and P = 0.05, respectively). Caspase-8 (-) patients who received postoperative radiotherapy presented a significantly increased disease-free survival compared to those who did not (P = 0.04). Patients bearing bax (-) tumors who received postoperative radiotherapy presented an improved four-year disease-free survival compared to bax (-) patients who did not receive any type of adjuvant radiotherapy (P = 0.017). CONCLUSION:
|
Authors | John Giotakis, Ilias P Gomatos, Leonidas Alevizos, Anastasia N Georgiou, Emmanuel Leandros, Manousos M Konstadoulakis, Leonidas Manolopoulos |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 142
Issue 4
Pg. 605-11
(Apr 2010)
ISSN: 1097-6817 [Electronic] England |
PMID | 20304286
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Biomarkers
- bcl-2-Associated X Protein
- Cytochromes c
- Caspase 8
|
Topics |
- Adenolymphoma
(chemistry)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(analysis)
- Caspase 8
(analysis)
- Cytochromes c
(analysis)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Parotid Neoplasms
(chemistry, mortality, radiotherapy, surgery)
- Radiotherapy, Adjuvant
- Survival Rate
- bcl-2-Associated X Protein
(analysis)
|