Induction with basiliximab in renal transplantation.

Abstract

INTRODUCTION:

The use of monoclonal antibodies in renal transplantation for induction therapy has been associated with a marked reduction in acute rejection rates with an impact on graft and patient survivals.

OBJECTIVE:

We sought to evaluate the efficacy of renal transplant induction protocols using Basiliximab based on the rates of acute rejection episodes (ARE) and delayed graft function (DGF) of infectious complications in the first 6 months posttransplant, as well as patient and graft survivals.

METHODS:

We retrospectively evaluated all renal transplants performed between 2000 and 2008 that were primary grafts from cadaveric heart-beating donors, into recipients with a panel reactive antibody titer <5% and who were treated with an immunosuppression scheme based on cyclosporine, mycophenolate mofetil/mycophenolic acid plus corticosteroids, with (group 1) or without basiliximab (group 2).

RESULTS:

We enrolled 52 recipients in group 1 (induction with basiliximab) and 189 in group 2 (without basiliximab). The baseline characteristics were similar among the groups, except for time on dialysis which was longer in group 1 and the number of HLA matches, which was lower in group 1. The ARE rate was lower among group 1 (7.8% vs 27.8%; P = .001); rates of DGF and infectious complications were similar. There was no significant difference in graft and patient survivals.

CONCLUSION:

In this study, induction with basiliximab was associated with a reduced rate rate of ARE, despite a lower number of HLA matches and a longer previous time on dialysis. The use of this induction modality was not associated with a greater rate of infectious complications.

• Authors: F Ferrer, S Machado, R Alves, F Macário, C Bastos, A Roseiro, A Mota
• Journal: Transplantation proceedings (Transplant Proc) Vol. 42 Issue 2 Pg. 467-70 (Mar 2010) ISSN: 1873-2623 [Electronic] United States
• PMID: 20304166 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2010 Elsevier Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Antibodies, Blocking
• Antibodies, Monoclonal
• HLA Antigens
• Immunosuppressive Agents
• Recombinant Fusion Proteins
• Cyclosporine
• Basiliximab
• Creatinine
• Mycophenolic Acid

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Antibodies, Blocking (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Basiliximab
• Creatinine (blood)
• Cyclosporine (therapeutic use)
• Female
• Graft Rejection (epidemiology)
• Graft Survival (drug effects)
• HLA Antigens (immunology)
• Histocompatibility Testing
• Humans
• Immunosuppressive Agents (therapeutic use)
• Kidney Transplantation (immunology, mortality)
• Male
• Middle Aged
• Mycophenolic Acid (analogs & derivatives, therapeutic use)
• Recombinant Fusion Proteins (therapeutic use)
• Retrospective Studies
• Survival Rate