Abstract | BACKGROUND & AIMS: METHODS: Patients with LPR symptoms were assigned randomly to receive rabeprazole (20 mg, twice daily, n = 42) or placebo (n = 40) for 12 weeks. All patients completed symptom questionnaires; these provided demographic information and the reflux symptom index before, during, and 6 weeks after cessation of treatment. Videolaryngostroboscopy was used to document the laryngeal findings and determine the reflux finding score. RESULTS: Twenty-four patients (57.1%) in the rabeprazole group and 27 patients (67.5%) in the placebo group had pH-documented LPR. The total reflux symptom index score decreased significantly in the group given rabeprazole, compared with patients given placebo, at weeks 6 and 12, but not at week 18. However, there were no significant differences in reflux finding scores between the rabeprazole and placebo groups at any of the time points. CONCLUSIONS: Twelve weeks of treatment with rabeprazole (20 mg, twice daily) significantly improved reflux symptoms, compared with placebo, in patients with LPR. Relapse of symptoms was observed 6 weeks after stopping PPI therapy, indicating the requirement for longer treatment duration in patients with LPR.
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Authors | Paul K Y Lam, Manwa L Ng, Ting K Cheung, Birgitta Y H Wong, Victoria P Y Tan, Daniel Y T Fong, William I Wei, Benjamin C Y Wong |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 8
Issue 9
Pg. 770-6
(Sep 2010)
ISSN: 1542-7714 [Electronic] United States |
PMID | 20303417
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Placebos
- Proton Pump Inhibitors
- Rabeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
(administration & dosage)
- Adult
- Aged
- Female
- Humans
- Laryngopharyngeal Reflux
(drug therapy, pathology)
- Laryngoscopy
- Male
- Middle Aged
- Placebos
(administration & dosage)
- Proton Pump Inhibitors
(administration & dosage)
- Rabeprazole
- Severity of Illness Index
- Stroboscopy
- Surveys and Questionnaires
- Treatment Outcome
- Videotape Recording
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