HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Serum parathyroid hormone and phosphate influence the levels of circulating CD34+ cells in uremia.

AbstractBACKGROUND:
Parathyroid hormone (PTH) is an active stimulator of bone marrow osteoblasts; it is involved in the niche organization, ie the bone marrow microenvironment which controls the turnover and the fate of endothelial progenitor cells (EPCs). PTH stimulates EPC production; this action can be measured by counting the number of circulating CD34+ cells.
METHODS:
This observational cross-sectional study aimed to verify this effect in 3 groups of hemodialysis patients with different serum PTH levels. The first group consisted of 11 patients affected by secondary hyperparathyroidism (SHPTH group, serum PTH levels >500 pg/ml); the second group consisted of 10 patients with serum PTH levels between 150 and 500 pg/ml (TargetPTH group); the third group consisted of 10 patients with serum PTH levels below the treatment target after parathyroidectomy (PTx group, serum PTH levels <150 pg/ml). Serum PTH, calcium (Ca), phosphorus (P), alkaline phosphatases (ALP), urea nitrogen, albumin and hemoglobin were measured. Flow cytofluorimetry with CD45+ sequential gating was effected; therefore, CD34+ cells could be analyzed.
RESULTS:
The SHPTH group showed significantly higher values of serum PTH, P and ALP (respectively, p<0.0001, p<0.033 and p<0.0001), and significantly lower values of circulating CD34+ cells (both in absolute and percent terms) in the SHPTH and in the TargetPTH groups (for both, p<0.0001). Two models of multiple regression analysis built with circulating CD34+ cells (expressed as percentage in the first one and as absolute values in the second one) as dependent variables showed that only serum PTH and P values were inversely associated with both.
CONCLUSIONS:
Our data suggest that an inverse relationship exists in uremic patients among circulating CD34+ cells and serum P and PTH levels. The count of circulating CD34+ cells might represent a novel biomarker for the assessment of the cardiovascular risk for dialysis patients.
AuthorsCarlo Lomonte, Clorinda Derosa, Luigi Vernaglione, Francesco Casucci, Nicola Losurdo, Pasquale Libutti, Annalisa Teutonico, Carlo Basile
JournalJournal of nephrology (J Nephrol) 2010 Nov-Dec Vol. 23 Issue 6 Pg. 693-8 ISSN: 1121-8428 [Print] Italy
PMID20301083 (Publication Type: Journal Article)
Chemical References
  • Antigens, CD34
  • Parathyroid Hormone
  • Phosphates
Topics
  • Adult
  • Aged
  • Antigens, CD34 (analysis)
  • Cell Count
  • Cross-Sectional Studies
  • Endothelial Cells (cytology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone (blood)
  • Phosphates (blood)
  • Stem Cells (cytology)
  • Uremia (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: