[Possibilities for optimizing radiotherapy of cancers of the ENT area by measuring oncoradiogenic enzyme peaks of glucose-6-phosphate isomerase].

Abstract

Blood samples were taken from 39 patients with head and neck carcinomas after the initial irradiation, and the activity of the glycolytic enzyme glucose-6-phosphate isomerase (GPI) was measured. All patients showed GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5-19.5 h after irradiation, was significantly correlated with tumour size and histological tumour differentiation. A late enzyme peak was associated with regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view, and the value of such enzyme peaks for the optimization of radiation therapy is pointed out.

• Authors: M Below, D Tunak, K H Dallüge, P Henkel, T Nicolai
• Journal: HNO (HNO) Vol. 39 Issue 1 Pg. 18-22 (Jan 1991) ISSN: 0017-6192 [Print] Germany
• Vernacular Title: Möglichkeiten der Optimierung der Strahlentherapie von Karzinomen im HNO-Bereich durch die Messung des onkoradiogenen Enzympeaks der Glukose-6-Phosphat-Isomerase (GPI).
• PMID: 2030082 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Cobalt Radioisotopes
• Glucose-6-Phosphate Isomerase

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood)
• Cobalt Radioisotopes (therapeutic use)
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Glucose-6-Phosphate Isomerase (blood)
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Pharyngeal Neoplasms (enzymology, radiotherapy, surgery)
• Radioisotope Teletherapy
• Radiotherapy Dosage
• Tongue Neoplasms (enzymology, radiotherapy, surgery)