Abstract | BACKGROUND: METHODS: A historic cohort study in patients with severe TBI [Glasgow Coma Scale (GCS) < or = 8 on admission]. RESULTS: Seventy-six of 119 patients survived and were eligible for follow-up. The incidence of dysautonomia was 11.8%. Episodes of dysautonomia were prevalent during a mean period of 20.1 days (range 3-68) and were often initiated by discomfort. Patients with dysautonomia showed significant longer periods of coma (24.78 vs. 7.99 days) and mechanical ventilation (22.67 vs. 7.21 days). Dysautonomia was associated with diffuse axonal injury (DAI) [relative risk (RR) 20.83, CI 4.92-83.33] and the development of spasticity (RR 16.94, CI 3.96-71.42). Patients with dysautonomia experienced more secondary complications. They tended to have poorer outcome. CONCLUSIONS:
Dysautonomia occurs in approximately 10% of patients surviving severe TBI and is associated with DAI and the development of spasticity at follow-up. The initiation of dysautonomia by discomfort supports the Excitatory: Inhibitory Ratio model as pathophysiological mechanism.
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Authors | H T Hendricks, A H Heeren, P E Vos |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 17
Issue 9
Pg. 1172-1177
(Sep 2010)
ISSN: 1468-1331 [Electronic] England |
PMID | 20298427
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Brain Injuries
(complications, diagnosis, physiopathology)
- Cohort Studies
- Disability Evaluation
- Female
- Glasgow Coma Scale
(standards)
- Humans
- Male
- Middle Aged
- Primary Dysautonomias
(diagnosis, etiology, physiopathology)
- Prognosis
- Severity of Illness Index
- Young Adult
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