Abstract | STUDY OBJECTIVE: METHODS: Fifty-five patients who had seized from alcohol withdrawal were randomly assigned to treatment with IV phenytoin or placebo. Patients with known seizure disorders and those receiving any anticonvulsant were excluded. The study was terminated after seizure recurrence or passage of a six-hour, high-risk seizure interval. RESULTS: Six of 28 phenytoin-treated patients (21%) had recurrent seizures compared with five of 27 placebo-treated patients (19%). The 95% confidence interval for the difference in response probabilities was +16% to -20%. There was no statistically significant difference between the response rates for the two treatments (P greater than .05). CONCLUSION:
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Authors | J F Chance |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 20
Issue 5
Pg. 520-2
(May 1991)
ISSN: 0196-0644 [Print] United States |
PMID | 2024792
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Double-Blind Method
- Emergencies
- Ethanol
(adverse effects)
- Humans
- Phenytoin
(therapeutic use)
- Prospective Studies
- Recurrence
- Seizures
(chemically induced, prevention & control)
- Substance Withdrawal Syndrome
(drug therapy)
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