5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome.

Abstract

Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53.8 mg). Eight eyes had undergone prior unsuccessful trabeculectomy. Four eyes had intraocular pressure (IOP) less than or equal to 21 mmHg on zero to two glaucoma medications after 6 to 54 months of follow-up (mean, 25.3 months). Five eyes required repeat surgery within 2 to 13 months and were considered failures. All five eyes that failed received a Molteno drainage implant. Progressive endothelial proliferation may explain late onset bleb failure and the relative ineffectiveness of 5-FU in this condition.

• Authors: M M Wright, A L Grajewski, S M Cristol, R K Parrish
• Journal: Ophthalmology (Ophthalmology) Vol. 98 Issue 3 Pg. 314-6 (Mar 1991) ISSN: 0161-6420 [Print] United States
• PMID: 2023751 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fluorouracil

Topics

• Adult
• Cataract Extraction
• Conjunctiva (drug effects)
• Corneal Diseases (drug therapy, surgery)
• Endothelium, Corneal
• Fluorouracil (therapeutic use)
• Follow-Up Studies
• Glaucoma (drug therapy, surgery)
• Humans
• Intraocular Pressure (drug effects)
• Keratoplasty, Penetrating
• Lenses, Intraocular
• Middle Aged
• Postoperative Complications (drug therapy, surgery)
• Prognosis
• Reoperation
• Syndrome
• Trabeculectomy