The prognostic value of the temporal course of S100beta protein in post-acute severe brain injury: A prospective and observational study.

Abstract

PRIMARY OBJECTIVE:

To study the predictive capacity of early S100beta samples for long-term outcome prediction after severe TBI.

METHODS AND PROCEDURES:

Eighty-seven patients with severe TBI were studied. Clinical and CT scan were taken at admission. S100beta concentration was quantified at admission and 24, 48 and 72 hours post-TBI (days 0, 1, 2 and 3). Outcome was assessed 12 months after discharge using Glasgow Outcome Score (GOS).

RESULTS:

Significant negative correlations were found between 1-year GOS and S100beta concentrations on days 1-3, but not on day 0. Deceased patients showed higher S100beta concentration than survivors on days 1-3. Good (GOS = 4-5) vs poor outcome (GOS = 1-3) differed significantly on day 3. Death outcome was independently predicted by day 2 (>2.37 microg l(-1)), day 3 (>1.41 microg l(-1)) samples and absence of pupillary reaction. Poor outcome was predicted independently only by pupillary reaction and the 72-hour sample (>1.1 microg l(-1)), but this predictive model was less satisfactory than the predictive model for death.

CONCLUSIONS:

A temporal profile of S100beta release from admission to 72 hours post-TBI is strongly recommended for use in identifying patients at risk of developing a worse outcome. The S100beta protein might be an early biomarker for predicting long-term outcome in patients with acute severe TBI.

• Authors: Francisco Murillo-Cabezas, Maria Angeles Muñoz-Sánchez, Maria Dolores Rincón-Ferrari, Juan Francisco Martín-Rodríguez, Rosario Amaya-Villar, Susana García-Gómez, José León-Carrión
• Journal: Brain injury (Brain Inj) Vol. 24 Issue 4 Pg. 609-19 ( 2010) ISSN: 1362-301X [Electronic] England
• PMID: 20235763 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Nerve Growth Factors
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (metabolism)
• Brain Injuries (metabolism, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Nerve Growth Factors (metabolism)
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Quality of Life
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins (metabolism)
• Survivors
• Time Factors
• Young Adult