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Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule.

Abstract
A single chain glycoprotein with an estimated molecular mass of 160 kD (gp160) was previously identified as a human lung tumor-associated antigen. This tumor marker is shown here to be associated noncovalently with a second 130-kD protein. Sequential immunoprecipitation studies of surface iodinated lung tumor cell lysates reveal that this heterodimeric complex is indistinguishable serologically and structurally from the integrin VLA-2, found originally on activated T lymphocytes and platelets. The VLA-2-like complex expressed on the lung tumors possesses similar characteristic Mg2+ dependent binding of collagen and laminin as observed with VLA-2 on normal cells. RNA analysis indicates that human lung tumors express at least 20 times more VLA-2 alpha chain message than normal adult human lung tissue. The results presented here raise the possibility that the overproduction of VLA-2 may be involved in the pathogenesis of human lung tumors by modulating the invasive and metastatic potential of the tumor.
AuthorsF A Chen, E A Repasky, R B Bankert
JournalThe Journal of experimental medicine (J Exp Med) Vol. 173 Issue 5 Pg. 1111-9 (May 01 1991) ISSN: 0022-1007 [Print] United States
PMID2022922 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Tumor-Associated, Carbohydrate
  • Biomarkers, Tumor
  • Cell Adhesion Molecules
  • Extracellular Matrix Proteins
  • Laminin
  • Receptors, Very Late Antigen
  • Collagen
Topics
  • Antigens, Tumor-Associated, Carbohydrate (analysis, genetics, metabolism)
  • Biomarkers, Tumor (analysis)
  • Blotting, Northern
  • Cell Adhesion Molecules (analysis, genetics, metabolism)
  • Collagen (metabolism)
  • Electrophoresis, Polyacrylamide Gel
  • Extracellular Matrix Proteins (chemistry, metabolism)
  • Gene Expression Regulation, Neoplastic (physiology)
  • Humans
  • Laminin (metabolism)
  • Lung Neoplasms (etiology, metabolism, pathology)
  • Neoplasm Metastasis (physiopathology)
  • Precipitin Tests
  • Receptors, Very Late Antigen (analysis, genetics, metabolism)
  • Tumor Cells, Cultured (metabolism, pathology, ultrastructure)

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