Abstract |
Biomarkers could be useful in evaluating immune reconstitution inflammatory syndrome (IRIS). A cohort of 45 HIV-1-infected, antiretroviral treatment (ART)-naive patients with baseline CD4 T cell counts <or=100 cells/microL who were started on ART, suppressed HIV- RNA to <50 copies/mL, and seen every 1-3 months for 1 year were retrospectively evaluated for suspected or confirmed IRIS. d-Dimer, C-reactive protein (CRP), and selected autoantibodies were analyzed at baseline, 1 and 3 months post-ART in cryopreserved plasma. Median differences between cases and controls were compared with Mann-Whitney and Fisher's exact tests. Sixteen patients (35.6%) developed IRIS (median of 35 days post-ART initiation): unmasking=8, paradoxical=7, autoimmune=1. Pre-ART d-dimer and CRP were higher in IRIS cases versus controls ( d-dimer: 0.89 mg/L versus 0.66 mg /L, p=0.037; CRP: 0.74 mg/L versus 0.39 mg/L, p=0.022), while d-dimer was higher in unmasking cases at IRIS onset (2.04 mg/L versus 0.36 mg /L, p=0.05). These biomarkers may be useful in identifying patients at risk for IRIS.
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Authors | Brian O Porter, G Laissa Ouedraogo, Jessica N Hodge, Margo A Smith, Alice Pau, Gregg Roby, Richard Kwan, Rachel J Bishop, Catherine Rehm, JoAnn Mican, Irini Sereti |
Journal | Clinical immunology (Orlando, Fla.)
(Clin Immunol)
Vol. 136
Issue 1
Pg. 42-50
(Jul 2010)
ISSN: 1521-7035 [Electronic] United States |
PMID | 20227921
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2010 Elsevier Inc. All rights reserved |
Chemical References |
- Anti-Retroviral Agents
- Autoantibodies
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- HLA-A Antigens
- fibrin fragment D
- C-Reactive Protein
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Topics |
- AIDS-Related Opportunistic Infections
(complications, immunology)
- Adult
- Anti-Retroviral Agents
(therapeutic use)
- Autoantibodies
(blood, immunology)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- CD4 Lymphocyte Count
- Female
- Fibrin Fibrinogen Degradation Products
(metabolism)
- HIV Infections
(blood, drug therapy)
- HIV-1
(isolation & purification)
- HLA-A Antigens
(genetics)
- Humans
- Immune Reconstitution Inflammatory Syndrome
(blood, diagnosis, epidemiology, etiology)
- Leukocyte Count
- Male
- Middle Aged
- Retrospective Studies
- Risk Factors
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