Outcomes of 75 patients over 12 years treated for acoustic neuromas with linear accelerator-based radiosurgery.

Abstract

The aim of this study was to investigate the efficacy of linear accelerator (LINAC)-based radiosurgery in the treatment of acoustic neuromas. In this retrospective study, we enrolled 75 patients with non-neurofibromatosis type 2 acoustic neuromas who were followed-up for more than 5years. The 75 patients were divided into 3 groups: patients with a newly diagnosed tumor; those with a residual tumor; and those with a recurrent tumor. The average follow-up period was 97.8months. The overall tumor progression-free rate was 92%, and corresponding rates among those with newly diagnosed tumors was 100%, residual tumors was 84.4%, and recurrent tumors was 92.8% (p=0.028). Lesion localization using CT scans correlated with a higher tendency for tumor progression than lesion localization using CT-MRI fusion images (15.6% versus 2.4%, respectively). Residual tumors treated with radiosurgery have a higher progression rate, and careful lesion localization using CT-MRI image fusion is required.

• Authors: Peng-Wei Hsu, Cheng-Nen Chang, Shih-Tseng Lee, Yin-Cheng Huang, Hsien-Chih Chen, Chun-Chieh Wang, Yung-Hsin Hsu, Chen-Kan Tseng, Yao-Liang Chen, Kuo-Cheng Wei
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 17 Issue 5 Pg. 556-60 (May 2010) ISSN: 1532-2653 [Electronic] Scotland
• PMID: 20227884 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Disease Progression
• Female
• Follow-Up Studies
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Neuroma, Acoustic (diagnostic imaging, surgery)
• Radiography
• Radiosurgery (instrumentation)
• Treatment Outcome