Langerhans cell histiocytosis with thyroid and lung involvement in a child: a case report.

Abstract

SUMMARY:

Langerhans cell histiocytosis (LCH), a monoclonal disease of histiocytes, may involve several organ systems but rarely primarily involves the thyroid gland. This report presents an extremely rare case of LCH of the thyroid and lungs in a 3-year-old boy who presented with a neck mass for several weeks. The patient subsequently underwent chemotherapy with resolution of the goiter and lung findings, and the patient remained in complete remission 1 year after chemotherapy. LCH of the thyroid should be considered in the differential diagnosis of a child with a thyroid mass. Pulmonary examination should be done in these patients.

• Authors: Chien-Heng Lin, Wei-Ching Lin, I-Ping Chiang, Yung-Jen Ho, Ching-Tien Peng, Kang-Hsi Wu
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 32 Issue 4 Pg. 309-11 (May 2010) ISSN: 1536-3678 [Electronic] United States
• PMID: 20224443 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child, Preschool
• Histiocytosis, Langerhans-Cell (complications, diagnosis, drug therapy)
• Humans
• Lung Diseases (etiology, pathology)
• Male
• Thyroid Diseases (etiology, pathology)
• Tomography, X-Ray Computed