Abstract |
This study compared the safety and efficacy of a non-prescription topical hemostatic powder (THP) containing a hydrophilic polymer and a potassium-based salt (group 1) to a sterile, compressed surgical sponge (group 2) for second intention healing (SIH) in 24 subjects following Mohs micrographic surgery (MMS) for the removal of non- melanoma skin cancers of the head and neck with a final defect size of 0.5 mm-2.0 cm. At least 50% of the subjects were receiving ongoing anti- coagulants. Hemostasis, rate of healing, wound size, global assessments of healing and application-site reactions were assessed. Time to hemostasis was measured at the time of surgery. Group 1 achieved hemostasis at a median of 52.5 seconds after the first stage of MMS versus 60 seconds in group 2. By week 12, wound size was reduced by a median of 182 mm2 in group 1 and 161.5 mm2 in group 2. A case series of subjects treated with THP following 4-mm punch biopsies is also discussed.
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Authors | Leon Kircik, James Q Del Rosso |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
Vol. 9
Issue 2
Pg. 137-40
(Feb 2010)
ISSN: 1545-9616 [Print] United States |
PMID | 20214176
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Topical
- Female
- Hemostatics
(administration & dosage, adverse effects)
- Humans
- Male
- Mohs Surgery
- Powders
- Sterilization
- Surgical Sponges
- Wound Healing
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