Effects of treatment with once-daily nifedipine CR and twice-daily benidipine on prevention of symptomatic attacks in patients with coronary spastic angina pectoris-Adalat Trial vs Coniel in Tokyo against Coronary Spastic Angina (ATTACK CSA).

Abstract

BACKGROUND:

We compared the efficacy of once-daily treatment with nifedipine CR 40 mg (NR) and twice-daily treatment with benidipine 4 mg (BD) in patients with coronary spastic angina (CSA) registered in 3 cardiovascular institutes in Tokyo.

METHODS AND RESULTS:

CSA was diagnosed by an ischemic ST change during Holter ECG monitoring or drug-induced test. Thirty patients were randomly allocated to either NR or BD group. The number of symptomatic attacks and the total frequency of short-acting nitrates were examined based on the data in diaries written by patients. There were no significant differences in the baseline characteristics between the two groups. The median number (25-75% quartile) of attacks per week was significantly decreased in NR group, i.e., 1.0 (0.8-2.0) at baseline, 0.0 (0.0-1.0) after 4 weeks of treatment, and 0.0 (0.0-0.0) after 8 weeks of treatment (P=0.0093, P=0.0002, Wilcoxon's rank-sum test). No significant decrease was observed in BD, i.e. 1.0 (0.5-2.0) at baseline, 1.3 (0.0-3.0) after 4 weeks, and 0.0 (0.0-1.0) after 8 weeks. The number of attacks was fewer in NR than in BD group (P=0.074, P=0.015, U-test for difference).

CONCLUSION:

Once-daily treatment with NR 40 mg was more effective than twice-daily treatment with BD in the prevention of CSA attacks.

• Authors: Yuji Oikawa, Syunsuke Matsuno, Junji Yajima, Masato Nakamura, Tsuyoshi Ono, Sugao Ishiwata, Yo Fujimoto, Tadanori Aizawa
• Journal: Journal of cardiology (J Cardiol) Vol. 55 Issue 2 Pg. 238-47 (Mar 2010) ISSN: 0914-5087 [Print] Netherlands
• PMID: 20206078 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright 2009 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Dihydropyridines
• Nitrates
• Vasodilator Agents
• benidipine
• Nifedipine
• Acetylcholine
• Ergonovine

Topics

• Acetylcholine
• Angina Pectoris (prevention & control)
• Blood Pressure (drug effects)
• Coronary Vasospasm (chemically induced, prevention & control)
• Dihydropyridines (administration & dosage)
• Electrocardiography, Ambulatory
• Ergonovine
• Female
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Nifedipine (administration & dosage)
• Nitrates (therapeutic use)
• Vasodilator Agents (administration & dosage)