Abstract |
In order to evaluate the effect of cerebral ischemia on the flavoprotein fluorescence (FPF), we compared the changes in the FPF and somatosensory evoked potential (SEP) during transient cerebral ischemia in the rat. We measured the FPF and SEP simultaneously via a cranial window made over the right sensorimotor cortex during the left median nerve stimulation in F344 rats. We compared change in FPF and SEP during cerebral ischemia for 60 min. The rCBF were rapidly recovered after reperfusion. However, the recovery rates of the FPF were significantly faster than those of the SEP after reperfusion. These findings indicate that activity-dependent changes of the FPF do not necessarily correlate with the electrical activity after transient cerebral ischemia.
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Authors | Takahiro Igarashi, Kaoru Sakatani, Tatsuya Hoshino, Norio Fujiwara, Yoshihiro Murata, Tsuneo Kano, Jun Kojima, Takamitsu Yamamoto, Yoichi Katayama |
Journal | Advances in experimental medicine and biology
(Adv Exp Med Biol)
Vol. 662
Pg. 95-100
( 2010)
ISSN: 0065-2598 [Print] United States |
PMID | 20204777
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Evoked Potentials, Somatosensory
(physiology)
- Flavoproteins
(metabolism)
- Fluorescence
- Ischemic Attack, Transient
(complications, physiopathology)
- Male
- Rats
- Rats, Inbred F344
- Reperfusion Injury
(complications, physiopathology)
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