Abstract | BACKGROUND: METHODS: Bile samples were collected by duodenal aspiration from 10 patients with proved variegate porphyria who had no neurologic symptoms when they were studied and 17 control subjects. Bile and fecal porphyrin levels were measured fluorometrically. RESULTS: The mean total porphyrin concentration in bile in the patients with variegate porphyria was significantly higher than that in the controls (67.8 vs. 0.71 mumol per liter; P less than 0.00002). There was more than a ninefold difference between the highest level in any control subject and the lowest level in any patient with variegate porphyria. The mean fecal porphyrin level in the patients with variegate porphyria also differed significantly from that in the controls (0.79 vs. 0.14 mumol per gram of dry weight; P less than 0.007), but four patients had levels within the control range. CONCLUSIONS:
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Authors | G M Logan, M K Weimer, M Ellefson, C A Pierach, J R Bloomer |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 324
Issue 20
Pg. 1408-11
(May 16 1991)
ISSN: 0028-4793 [Print] United States |
PMID | 2020296
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Bile
(chemistry)
- Feces
(chemistry)
- Female
- Humans
- Male
- Middle Aged
- Porphyrias
(diagnosis, metabolism)
- Porphyrins
(analysis, metabolism)
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