Transient global amnesia as the presenting feature of heparin-induced thrombocytopenia.

Abstract

A 57-year-old man developed transient global amnesia within an hour of bolus unfractionated heparin administration on day 4 post-mitral valve replacement. Both immunoglobulin G-specific enzyme-linked immunosorbent assay and serotonin release assay were strongly positive for the antibodies that cause heparin-induced thrombocytopenia. The patient's cognitive functions returned to normal following discontinuation of unfractionated heparin and warfarin and commencement of lepirudin infusion.

• Authors: Chun Huat Teh, Martyn N Robertson, Theodore E Warkentin, Peter A Henriksen, Edward T Brackenbury, Julia A M Anderson
• Journal: Journal of cardiac surgery (J Card Surg) Vol. 25 Issue 3 Pg. 300-2 (May 2010) ISSN: 1540-8191 [Electronic] United States
• PMID: 20202039 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Hirudins
• Recombinant Proteins
• Warfarin
• Heparin
• lepirudin

Topics

• Amnesia, Transient Global (chemically induced, diagnosis)
• Anticoagulants (adverse effects, therapeutic use)
• Heart Valve Prosthesis Implantation
• Heparin (adverse effects)
• Hirudins
• Humans
• Male
• Middle Aged
• Mitral Valve (pathology)
• Recombinant Proteins (therapeutic use)
• Thrombocytopenia (chemically induced, complications)
• Time Factors
• Warfarin (adverse effects)