Anticancer activity of osmium metalla-rectangles.

Abstract

A series of cationic metalla-rectangles of the general formula [(p-cymene)(4)Os(4)(OO[intersection]OO)(2)(N[intersection]N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2)Os(2)(OO[intersection]OO)(2)Cl(2)] (OO[intersection]OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (N[intersection]N = 4,4'-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF(3)SO(3). All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)(4)Os(4)(dhbq)(2)(4,4'-bipyridine)(2)](4+), shows an IC(50) value of 5.7 microM (comparable to cisplatin) against A2780 cancer cells and 7.5 microM against the cisplatin resistant A2780cisR cells.

• Authors: Nicolas P E Barry, Fabio Edafe, Paul J Dyson, Bruno Therrien
• Journal: Dalton transactions (Cambridge, England : 2003) (Dalton Trans) Vol. 39 Issue 11 Pg. 2816-20 (Mar 21 2010) ISSN: 1477-9234 [Electronic] England
• PMID: 20200707 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Cations
• Coordination Complexes
• Pyridines
• Osmium
• pyridine

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, toxicity)
• Cations (chemistry)
• Cell Line, Tumor
• Coordination Complexes (chemical synthesis, chemistry, toxicity)
• Humans
• Magnetic Resonance Spectroscopy
• Osmium (chemistry)
• Pyridines (chemistry)
• Spectrophotometry, Ultraviolet