Successful allogeneic bone marrow transplantation for diamond-blackfan anemia complicated by severe cardiac dysfunction due to transfusion-induced hemochromatosis.

Abstract

A 21-year-old man who was diagnosed with Diamond-Blackfan anemia at 2 years of age came to our hospital with the hope of undergoing bone marrow transplantation (BMT). He had been red cell transfusion-dependent for about 8 years; at presentation he had transfusion-induced hemochromatosis, a subsequent low left ventricular ejection fraction (LVEF) of 43%, and diabetes mellitus requiring insulin therapy. He received unrelated BMT with reduced intensity conditioning and sufficient GVHD prophylaxis. Regardless of the cardiac dysfunction, he had an uneventful course during pre- and post-grafting periods, and is currently doing well with an improved LVEF (55%), although he is still insulin dependent.

• Authors: Sumie Tabata, Minako Mori, Yuya Nagai, Hisako Hashimoto, Hiroshi Arima, Seiji Nagano, Yoko Takiuchi, Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Soshi Yanagita, Kiminari Ito, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 49 Issue 5 Pg. 453-6 ( 2010) ISSN: 1349-7235 [Electronic] Japan
• PMID: 20190482 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hypoglycemic Agents
• Insulin

Topics

• Anemia, Diamond-Blackfan (therapy)
• Bone Marrow Transplantation
• Diabetes Mellitus (drug therapy, etiology)
• Hemochromatosis (complications, etiology)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Male
• Transfusion Reaction
• Transplantation, Homologous
• Ventricular Dysfunction, Left (diagnosis, etiology)
• Young Adult