Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children.

Abstract

Serum levels of glutathione reductase (GR), glutathione S-transferase-alpha (GST-alpha) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-alpha and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3 markers for detecting hepatitis B virus, hepatitis C virus and schistosomiasis infection respectively were: 16.7%, 100.0% and 17.7% for GR; 33.3%, 62.1% and 38.2% for GST-alpha; and 25.0%, 10.3% and 29.4% for MDA. GR was more sensitive in hepatitis C infection, while MDA reflected changes in liver ultrasound and GST-alpha was the best indicator for histopathological changes.

• Authors: K A Mahdy, A Abd-El-Shaheed, M E Khadr, K A I El-Shamy
• Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (East Mediterr Health J) 2009 Jul-Aug Vol. 15 Issue 4 Pg. 842-52 ISSN: 1020-3397 [Print] Egypt
• PMID: 20187535 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)

Chemical References

• Antioxidants
• Biomarkers
• Malondialdehyde
• Glutathione Reductase
• Glutathione Transferase

Topics

• Adolescent
• Analysis of Variance
• Antioxidants (metabolism)
• Biomarkers (metabolism)
• Biopsy
• Case-Control Studies
• Child
• Child, Preschool
• Egypt
• Female
• Glutathione Reductase (blood)
• Glutathione Transferase (blood)
• Hepatitis B (complications)
• Hepatitis C (complications)
• Humans
• Lipid Peroxidation
• Liver Diseases (diagnosis, etiology, metabolism)
• Liver Function Tests
• Male
• Malondialdehyde (blood)
• Schistosomiasis (complications)
• Sensitivity and Specificity
• Severity of Illness Index