Abstract | PURPOSE: MATERIALS AND METHODS: A total of 24 rats, divided into three groups with n = 8 animals per group, were evaluated. Animals in group 1 received injections of gadobutrol and gadopentetate dimeglumine, whereas those in group 2 received gadobutrol and gadoterate meglumine. Injections were performed in random order and separated by 24 hours. Magnetic resonance imaging (MRI) examinations were performed immediately following each contrast injection with a 1.5 T MR system. Animals in group 3 received gadobutrol injections using the same protocol but with scans performed at 1.5 and 3 T. In all examinations, T1-weighted images were acquired precontrast, 1 minute postcontrast, and at 4 consecutive 2-minute intervals thereafter. A contrast dose of 0.1 mmol/kg was used in all instances. RESULTS: In groups 1 and 2, tumor signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were higher for gadobutrol compared to both other agents at each timepoint postcontrast injection. The improvement in tumor CNR with gadobutrol, depending on time, was between 12% and 40% versus gadopentetate dimeglumine, with the difference achieving statistical significance at 7 minutes. The improvement in tumor CNR with gadobutrol, depending on time, was between 15% and 27% versus gadoterate meglumine, with the difference statistically significant at 5 and 9 minutes. In group 3 the improvement in tumor SNR and CNR seen with the increase in field strength from 1.5 to 3 T for gadobutrol was statistically significant at all acquired timepoints (P < 0.002). CNR mean values ranged from 10.4 +/- 2.9 to 24.6 +/- 5.0 at 1.5 T and from 20.5 +/- 5.9 to 47.8 +/- 15.7 at 3 T depending on the timepoint postcontrast. CONCLUSION:
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Authors | Ulrike I Attenberger, Val M Runge, John N Morelli, Jonathan Williams, Carney B Jackson, Henrik J Michaely |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 31
Issue 3
Pg. 549-55
(Mar 2010)
ISSN: 1522-2586 [Electronic] United States |
PMID | 20187196
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chelating Agents
- Ions
- Organometallic Compounds
- gadobutrol
- Meglumine
- Gadolinium DTPA
- gadoterate meglumine
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Topics |
- Animals
- Brain Neoplasms
(diagnosis)
- Cell Line, Tumor
- Chelating Agents
- Disease Models, Animal
- Gadolinium DTPA
- Glioma
(diagnosis)
- Humans
- Ions
- Magnetic Resonance Imaging
(methods)
- Meglumine
- Organometallic Compounds
- Rats
- Rats, Inbred F344
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