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Potent vesicular stomatitis virus-based avian influenza vaccines provide long-term sterilizing immunity against heterologous challenge.

Abstract
The emergence in 1997 and continuance today of a highly lethal H5N1 avian influenza virus (AIV) causing human disease has raised concern about an impending pandemic and the need for a vaccine to prepare for such an occurrence. We previously generated an efficacious vesicular stomatitis virus (VSV)-based AIV vaccine expressing H5 hemagglutinin (HA) from the fifth genomic position of VSV (J. A. Schwartz et al., Virology 366:166-173, 2007). Here we have generated and characterized VSV-based vaccines that express the A/Hong Kong/156/1997 (clade 0) H5 HA from the first position of the VSV genome. These vectors induce broadly cross-neutralizing antibodies against homologous and heterologous H5N1 viruses of different clades in mice. The vaccines provide complete protection against morbidity and mortality after heterologous challenge with clade 0 and clade 1 strains in animals even 1 year after vaccination. Postchallenge pulmonary virus loads show that these vectors provide sterilizing immunity. Therefore, VSV-based AIV vaccines are potent, broadly cross-protective pandemic vaccine candidates.
AuthorsJennifer A Schwartz, Linda Buonocore, Amorsolo L Suguitan Jr, Alex Silaghi, Darwyn Kobasa, Gary Kobinger, Heinz Feldmann, Kanta Subbarao, John K Rose
JournalJournal of virology (J Virol) Vol. 84 Issue 9 Pg. 4611-8 (May 2010) ISSN: 1098-5514 [Electronic] United States
PMID20181720 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Influenza Vaccines
  • hemagglutinin, avian influenza A virus
Topics
  • Animals
  • Antibodies, Neutralizing (blood)
  • Antibodies, Viral (blood)
  • Body Weight
  • Cross Protection
  • Female
  • Genetic Vectors
  • Hemagglutinin Glycoproteins, Influenza Virus (genetics, immunology)
  • Influenza A Virus, H5N1 Subtype (immunology)
  • Influenza Vaccines (genetics, immunology)
  • Lung (virology)
  • Mice
  • Mice, Inbred BALB C
  • Orthomyxoviridae Infections (prevention & control, virology)
  • Survival Analysis
  • Time Factors
  • Vesiculovirus (genetics)
  • Viral Plaque Assay

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