Abstract | PURPOSE: In this prospective, randomized, double-blinded study we sought to evaluate the efficacy and safety of combined use of intravenous ketorolac and acetaminophen in small children undergoing outpatient inguinal hernia repair. MATERIALS AND METHODS: We studied 55 children 1 to 5 years old who were undergoing elective repair of unilateral inguinal hernia. After induction of general anesthesia children in the experimental group (28 patients) received 1 mg/kg ketorolac and 20 mg/kg acetaminophen intravenously. In the control group (27 patients) the same volume of saline was administered. All patients received 1 microg/kg fentanyl intravenously before incision. We also evaluated the number of patients requiring postoperative rescue fentanyl, total fentanyl consumption, pain scores and side effects. RESULTS: Significantly fewer patients receiving ketorolac- acetaminophen received postoperative rescue fentanyl compared to controls (28.6% vs 81.5%). A significantly lower total dose of fentanyl was administered to patients receiving ketorolac- acetaminophen compared to controls (0.54 vs 1.37 microg/kg). Pain scores were significantly higher in the control group immediately postoperatively but eventually decreased. The incidences of sedation use (55.6% vs 25.0%) and vomiting (33.3% vs 10.7%) were significantly higher in controls. CONCLUSIONS:
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Authors | Jeong-Yeon Hong, Sang Won Han, Won Oak Kim, Hae Keum Kil |
Journal | The Journal of urology
(J Urol)
Vol. 183
Issue 4
Pg. 1551-5
(Apr 2010)
ISSN: 1527-3792 [Electronic] United States |
PMID | 20172547
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Anti-Inflammatory Agents, Non-Steroidal
- Acetaminophen
- Fentanyl
- Ketorolac
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Topics |
- Acetaminophen
(administration & dosage)
- Ambulatory Surgical Procedures
- Analgesics, Non-Narcotic
(administration & dosage)
- Analgesics, Opioid
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Child, Preschool
- Double-Blind Method
- Drug Therapy, Combination
- Fentanyl
(administration & dosage)
- Hernia, Inguinal
(surgery)
- Humans
- Infant
- Infusions, Intravenous
- Ketorolac
(administration & dosage)
- Pain, Postoperative
(prevention & control)
- Prospective Studies
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