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High dose of ascorbic acid induces cell death in mesothelioma cells.

Abstract
Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. Recently, high dose of ascorbate in cancer treatment has been reexamined. We studied whether high dose of ascorbic acid induced cell death of four human mesothelioma cell lines. High dose of ascorbic acid induced cell death of all mesothelioma cell lines in a dose-dependent manner. We further clarified the cell killing mechanism that ascorbic acid induced reactive oxygen species and impaired mitochondrial membrane potential. In vivo experiment, intravenous administration of ascorbic acid significantly decreased the growth rate of mesothelioma tumor inoculated in mice. These data suggest that ascorbic acid may have benefits for patients with mesothelioma.
AuthorsYukitoshi Takemura, Motohiko Satoh, Kiyotoshi Satoh, Hironobu Hamada, Yoshitaka Sekido, Shunichiro Kubota
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 394 Issue 2 Pg. 249-53 (Apr 02 2010) ISSN: 1090-2104 [Electronic] United States
PMID20171954 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright2010 Elsevier Inc. All rights reserved.
Chemical References
  • Reactive Oxygen Species
  • Ascorbic Acid
Topics
  • Animals
  • Apoptosis
  • Ascorbic Acid (administration & dosage)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Humans
  • Membrane Potential, Mitochondrial (drug effects)
  • Mesothelioma (drug therapy)
  • Mice
  • Mice, SCID
  • Reactive Oxygen Species (metabolism)
  • Xenograft Model Antitumor Assays

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