Abstract | RATIONALE: OBJECTIVES: METHODS: Transbronchial biopsies were performed at defined intervals with prospective cytomegalovirus immunostaining on every biopsy (n = 1,887). Cox proportional hazards models were used to assess the relationship between treated cytomegalovirus pneumonitis and clinical outcomes. MEASUREMENTS AND MAIN RESULTS: Forty-nine (21%) recipients developed cytomegalovirus pneumonitis a median of 106 days after transplantation. Treated cytomegalovirus pneumonitis within the first 6 months after transplantation significantly increased the risk for bronchiolitis obliterans syndrome (P = 0.001; hazard ratio, 2.19; 95% confidence interval, 1.36-3.51) and post- transplantation death (P = 0.02; hazard ratio, 1.89; 95% confidence interval, 1.11-3.23). This risk persisted when cytomegalovirus pneumonitis was considered as a time-dependent predictor as well as in multivariable models controlling for other risk factors. CONCLUSIONS:
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Authors | Laurie D Snyder, C Ashley Finlen-Copeland, W Jackson Turbyfill, David Howell, Daniel A Willner, Scott M Palmer |
Journal | American journal of respiratory and critical care medicine
(Am J Respir Crit Care Med)
Vol. 181
Issue 12
Pg. 1391-6
(Jun 15 2010)
ISSN: 1535-4970 [Electronic] United States |
PMID | 20167845
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Ganciclovir
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Topics |
- Adult
- Antiviral Agents
(therapeutic use)
- Bronchiolitis Obliterans
(virology)
- Cohort Studies
- Cytomegalovirus Infections
(drug therapy, virology)
- Female
- Ganciclovir
(therapeutic use)
- Humans
- Lung Transplantation
(adverse effects)
- Middle Aged
- Pneumonia, Viral
(drug therapy, virology)
- Postoperative Complications
(virology)
- Proportional Hazards Models
- Risk Factors
- Survival Analysis
- Syndrome
- Treatment Outcome
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