Sodium fluoride in otosclerosis treatment: review.

Abstract

OBJECTIVES:

To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.

DESIGN:

A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms 'otosclerosis' and 'fluoride'. Article abstracts were reviewed and relevant full articles acquired.

RESULTS:

There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case-control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.

CONCLUSIONS:

There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.

• Authors: A S Cruise, A Singh, R E Quiney
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 124 Issue 6 Pg. 583-6 (Jun 2010) ISSN: 1748-5460 [Electronic] England
• PMID: 20163750 (Publication Type: Journal Article, Review)

Chemical References

• Sodium Fluoride

Topics

• Animals
• Hearing Loss (prevention & control)
• Humans
• Otosclerosis (diagnosis, drug therapy)
• Sodium Fluoride (therapeutic use)
• Tomography, X-Ray Computed