Abstract | IMPORTANCE OF THE FIELD: AREAS COVERED IN THIS REVIEW: We conducted a PubMed literature search using the keywords COPD, albuterol, ipratropium bromide and Combivent (Boehringer Ingelheim Corp., Ridgefield, CT, USA); pertinent references within the identified citations are included in the review. Data from the manufacturers are also evaluated. WHAT THE READER WILL GAIN: At the time of its approval, albuterol/ipratropium bromide was an innovative combination of existing medications for the treatment of COPD. The combined formulation provides better improvement in airflow than either component alone and, by reducing the number of separate inhalers, simplifies therapy and improves compliance compared with the individual components. TAKE HOME MESSAGE: The recent development and approval of longer acting and more potent beta agonists, anticholinergics and newer combination treatments have surpassed many of the advantages of combined albuterol-ipratropium for the treatment of patients with stable COPD.
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Authors | Joshiah Gordon, Ralph J Panos |
Journal | Expert opinion on drug metabolism & toxicology
(Expert Opin Drug Metab Toxicol)
Vol. 6
Issue 3
Pg. 381-92
(Mar 2010)
ISSN: 1744-7607 [Electronic] England |
PMID | 20163324
(Publication Type: Journal Article, Review)
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Chemical References |
- Albuterol, Ipratropium Drug Combination
- Bronchodilator Agents
- Ipratropium
- Albuterol
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Topics |
- Albuterol
(adverse effects, chemistry, pharmacology, therapeutic use)
- Albuterol, Ipratropium Drug Combination
- Bronchodilator Agents
(adverse effects, chemistry, pharmacology, therapeutic use)
- Clinical Trials as Topic
- Humans
- Ipratropium
(adverse effects, chemistry, pharmacology, therapeutic use)
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
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