[A case of refractory pulmonary peripheral T cell lymphoma successfully treated with Cisplatin Plus Gemcitabine Plus Solumedrol].

Abstract

A 56-year-old man had an endoscopic examination for dysphagia in March 2007 which revealed tumors in the esophagus and stomach. Pathological examination of the esophagus biopsy specimens showed an unspecified peripheral T cell lymphoma. The esophagus tumor was tolerant to CHOP and EPOCH therapy. After an autologous peripheral blood stem cell transplantation, a complete response was observed in the patient. However, a lymphoma relapse was diagnosed in the lung in September 2008. The relapsed lung lymphoma was tolerant to EPOCH therapy. The refractory pulmonary peripheral T cell lymphoma was remarkably reduced by PEGS therapy. PEGS therapy is useful for relapsed peripheral T cell lymphoma cases that tolerated standard chemotherapy. An allogenic hematopoietic stem cell transplantation or new molecular target therapy might be finally selected for refractory peripheral T cell lymphoma. However, an allogenic transplantation has some severe complications. Furthermore we could not easily try phase I or II new molecular target drug treatment. We think that PEGS therapy is a useful treatment for refractory peripheral T cell lymphoma before allogenic transplantation or new molecular target drug treatment.

• Authors: Yoshiki Uemura, Toshi Imai, Takeshi Nakajim, Tomoyuki Urata, Hiroyuki Doi
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 48 Issue 1 Pg. 28-32 (Jan 2010) ISSN: 1343-3490 [Print] Japan
• PMID: 20163018 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Antineoplastic Agents, Hormonal
• Deoxycytidine
• Methylprednisolone Hemisuccinate
• Cisplatin
• Gemcitabine

Topics

• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Agents, Hormonal (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Humans
• Lung Neoplasms (drug therapy)
• Lymphoma, T-Cell, Peripheral (drug therapy)
• Male
• Methylprednisolone Hemisuccinate (administration & dosage)
• Middle Aged
• Recurrence
• Gemcitabine