Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis.

Abstract

BACKGROUND:

Little is known about the association of scavenger receptor class B type I (SCARB1) single-nucleotide polymorphisms (SNPs) and subclinical atherosclerosis, particularly in subjects of different racial/ethnic backgrounds. We examined this relationship in the Multi-Ethnic Study of Atherosclerosis.

METHODS AND RESULTS:

Forty-three SCARB1-tagging SNPs were genotyped. Baseline examinations included fasting lipids and subclinical atherosclerosis phenotypes (coronary artery calcification, common carotid intimal-medial artery thickness [CCIMT], and internal carotid intimal-medial artery thickness). Examining SNP associations with different subclinical atherosclerosis phenotypes across multiple racial/ethnic groups with adjustment for multiple covariates, we found that the C allele of SNP rs10846744 was associated with higher CCIMT in African American (P=0.03), Chinese (P=0.02), European American (P=0.05), and Hispanic participants (P=0.03) and was strongly associated in pooled analyses (P=0.0002). The results also showed that the association of this SNP with CCIMT was independent of lipids and other well-established cardiovascular risk factors. Stratifying by sex, there seemed to be a strong association of rs10846744 with CCIMT in women, but no genotype-sex interactions were observed.

CONCLUSIONS:

Variation in SCARB1 at rs10846744 was significantly associated with CCIMT across racial/ethnic groups in Multi-Ethnic Study of Atherosclerosis.

• Authors: Adam C Naj, Michael West, Stephen S Rich, Wendy Post, W H Linda Kao, Bruce A Wasserman, David M Herrington, Annabelle Rodriguez
• Journal: Circulation. Cardiovascular genetics (Circ Cardiovasc Genet) Vol. 3 Issue 1 Pg. 47-52 (Feb 2010) ISSN: 1942-3268 [Electronic] United States
• PMID: 20160195 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• SCARB1 protein, human
• Scavenger Receptors, Class B

Topics

• Black or African American (genetics)
• Aged
• Aged, 80 and over
• Alleles
• Asian People (genetics)
• Atherosclerosis (ethnology, genetics)
• Carotid Arteries (physiology)
• Female
• Genetic Predisposition to Disease
• Genotype
• Hispanic or Latino (genetics)
• Humans
• Male
• Middle Aged
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors
• Scavenger Receptors, Class B (genetics)
• Sex Factors
• Tunica Intima (physiology)
• White People (genetics)