Abstract | OBJECTIVE: METHODS: The study design was a balanced provocation study. Twenty-three patients with FHM and 11 healthy controls received a continuous IV infusion of 0.5 mug/kg/min GTN over 20 minutes. RESULTS: We found no difference in the incidence of migraine-like attacks comparing all patients with FHM (30%) to controls (9%) (p = 0.15). Patients with FHM with coexisting MA or MO reported more migraine attacks after GTN (55%) than patients with the pure FHM phenotype (8.3%) (p = 0.02). Compared to healthy controls, more patients with FHM with coexisting MA or MO reported migraine-like attacks than controls (p = 0.03), whereas the FHM group with the pure FHM phenotype did not (p > 0.05). CONCLUSIONS:
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Authors | Jakob Møller Hansen, Lise Lykke Thomsen, Jes Olesen, Messoud Ashina |
Journal | Neurology
(Neurology)
Vol. 74
Issue 7
Pg. 594-600
(Feb 16 2010)
ISSN: 1526-632X [Electronic] United States |
PMID | 20157162
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Analgesics
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Migraine Disorders
(chemically induced, complications, drug therapy)
- Migraine with Aura
(chemically induced, complications, drug therapy)
- Migraine without Aura
(chemically induced, complications, drug therapy)
- Nitroglycerin
- Severity of Illness Index
- Time Factors
- Young Adult
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