Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis: association with severity of pulmonary fibrosis.

Abstract

OBJECTIVE:

To determine serum concentrations and clinical association of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with systemic sclerosis (SSc).

METHODS:

Serum sTREM-1 levels from 17 patients with limited cutaneous SSc (lSSc), 24 patients with diffuse cutaneous SSc (dSSc), and 29 healthy control individuals were examined by ELISA.

RESULTS:

Total SSc patients exhibited significantly elevated serum sTREM-1 levels relative to controls (p < 0.01). Serum sTREM-1 levels were significantly elevated in patients with dSSc compared to controls (p < 0.005) and lSSc patients (p < 0.05). By contrast, sTREM-1 levels in lSSc were similar to those in controls. Serum sTREM-1 levels were significantly elevated in SSc patients with decreased percentage vital capacity (%VC). Consistent with this, serum sTREM-1 levels in SSc patients correlated negatively with %VC (r = -0.24, p < 0.005). Among SSc patients with pulmonary fibrosis, sTREM-1 levels were significantly increased in patients with decreased %VC or decreased percentage of diffusion capacity for carbon monoxide relative to those with normal values (p < 0.05).

CONCLUSION:

Serum sTREM-1 levels were elevated in dSSc patients and correlated with severity of pulmonary fibrosis, suggesting that serum sTREM-1 is a novel serological marker for the disease severity of SSc.

• Authors: Hajime Tomita, Fumihide Ogawa, Toshihide Hara, Koichi Yanaba, Yohei Iwata, Eiji Muroi, Ayumi Yoshizaki, Kazuhiro Komura, Motoi Takenaka, Kazuhiro Shimizu, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 37 Issue 4 Pg. 787-91 (Apr 2010) ISSN: 0315-162X [Print] Canada
• PMID: 20156945 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Membrane Glycoproteins
• Receptors, Immunologic
• TREM1 protein, human
• Triggering Receptor Expressed on Myeloid Cells-1

Topics

• Adult
• Aged
• Biomarkers (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Membrane Glycoproteins (blood)
• Middle Aged
• Pulmonary Fibrosis (blood, complications)
• Receptors, Immunologic (blood)
• Scleroderma, Diffuse (blood, complications)
• Scleroderma, Limited (blood, complications)
• Severity of Illness Index
• Triggering Receptor Expressed on Myeloid Cells-1