Synchronous hepatic, mesenteric and pulmonary Epstein-Barr virus-associated smooth muscle tumors in a renal transplant recipient.

Abstract

Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are distinct lesions that occur in immunocompromised patients. EBV-SMT following solid organ transplantation are rare and generally have an indolent biological behavior. Post-transplant EBV-SMT have been reported in various anatomical locations. This report describes a synchronous and multicentric development of EBV-SMT in liver, mesentery, and lung of a 33-yr-old male patient, 10 yr after a deceased allograft renal transplantation. The hepatic and mesenteric tumors were available for study. These tumors were composed of bland looking, desmin-positive, spindle-shaped cells which showed a strong nuclear staining for EBV with in situ hybridization technique. A literature review of post solid organ transplant EBV-SMT in the liver and lung, particularly regarding their pathogenesis, synchronicity and biological behavior would be provided.

• Authors: T Al Hussain, A Haleem, K O Alsaad
• Journal: Clinical transplantation (Clin Transplant) 2010 Sep-Oct Vol. 24 Issue 5 Pg. 579-84 ISSN: 1399-0012 [Electronic] Denmark
• PMID: 20156224 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2010 John Wiley & Sons A/S.

Chemical References

• Biomarkers, Tumor

Topics

• Adult
• Biomarkers, Tumor (analysis)
• Epstein-Barr Virus Infections (pathology, virology)
• Herpesvirus 4, Human (isolation & purification)
• Humans
• Immunoenzyme Techniques
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation
• Laparotomy
• Liver Neoplasms (chemistry, pathology, virology)
• Lung Neoplasms (chemistry, pathology, virology)
• Male
• Mesentery (pathology, virology)
• Neoplasms, Multiple Primary (chemistry, pathology, virology)
• Peritoneal Neoplasms (chemistry, pathology, virology)
• Smooth Muscle Tumor (chemistry, pathology, virology)
• Tomography, X-Ray Computed
• Transplantation, Homologous