The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or
insulin resistance. Premenopausal obese women, aged 35-52 years, were studied. GH secretion,
IGF-I, serum cardiovascular risk markers,
insulin,
leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was <or=3 microg/L. Mean total and
LDL cholesterol, fasting
insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting
insulin (R = -0.650, P = .012), HOMA-IR (R = -0.846, P = .001), total
cholesterol (R = -0.532, P = .034), and
LDL cholesterol (R = -0.692, P = .006) and positively associated with
HDL cholesterol (R = 0.561, P = .037). These data strongly suggest a role for
insulin resistance in the decreased GH secretion of
obesity and that the blunted GH secretion of
central obesity could be the pituitary expression of the
metabolic syndrome.