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Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia.

AbstractOBJECTIVE:
Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery. It is a regulator of uterine contractions, of vascular resistance and of volume of the retroplacental blood pool. Recently, it was shown that it could also regulate metalloproteinase 9 activity and thus, invasiveness of trophoblastic cells. Since development of preeclampsia could be initiated by decreased cytotrophoblastic invasion of spiral arterioles and a reduced uteroplacental perfusion, we speculate that circulating P-LAP activity could be decreased during preeclampsia.
MATERIALS AND METHODS:
Case-control study was evaluated in 84 women. P-LAP activity was measured in n=51 healthy pregnant women at term, and compared with n=16 normotensive women delivering preterm and n=17 women diagnosed with pre-eclampsia. P-LAP activity was determined by colorimetry in plasma samples using L-Leucine-p-nitroanilide as substrate.
RESULTS:
P-LAP activity was significantly lower in sera of preeclamptic women (0.91+/-0.122 mDO/min) as compared to normotensive controls (1.41+/-0.103 mDO/min; p=0.003) irrespective of time of delivery.
CONCLUSIONS:
These findings confirm the probable involvement of P-LAP in trophoblast invasion and development of preeclampsia.
AuthorsRuth Landau, Alexandra Laverrière, Paul Bischof, Olivier Irion, Michel Morales, Marie Cohen
JournalNeuro endocrinology letters (Neuro Endocrinol Lett) Vol. 31 Issue 1 Pg. 63-6 ( 2010) ISSN: 0172-780X [Print] Sweden
PMID20150869 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cystinyl Aminopeptidase
  • leucyl-cystinyl aminopeptidase
Topics
  • Case-Control Studies
  • Cystinyl Aminopeptidase (blood, metabolism)
  • Down-Regulation
  • Enzyme Activation
  • Female
  • Gestational Age
  • Humans
  • Pre-Eclampsia (blood, enzymology, metabolism)
  • Pregnancy
  • Premature Birth (blood, enzymology, metabolism)
  • Severity of Illness Index
  • Term Birth (blood, metabolism)

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