Abstract |
Tremor is one of the most disabling symptoms in patients with movement disorders such as Parkinson's disease (PD) and essential tremor (ET). Spike trains extracted from microelectrode recordings are used to study the relationship of tremor exhibited by neuronal signals to physical tremor as measured with electromyograms (EMG), gyroscopes, or accelerometers. We describe a new method for continuously tracking the instantaneous tremor frequency and amplitude in spike trains based on a new state-space model and the extended Kalman smoother. This method can be used to detect periods of statistically significant tremor in recordings with intermittent tremor.
|
Authors | Sunghan Kim, James McNames |
Journal | Journal of neuroscience methods
(J Neurosci Methods)
Vol. 188
Issue 1
Pg. 97-104
(Apr 30 2010)
ISSN: 1872-678X [Electronic] Netherlands |
PMID | 20149825
(Publication Type: Journal Article)
|
Copyright | Copyright 2010 Elsevier B.V. All rights reserved. |
Topics |
- Algorithms
- Computer Simulation
- Electrodes, Implanted
- Electromyography
- Humans
- Microelectrodes
- Models, Neurological
- Neurons
(physiology)
- Signal Processing, Computer-Assisted
- Tremor
(physiopathology)
|