Abstract | OBJECTIVE: DESIGN: A case control association study investigating nine Tag SNPs within FcGRIIa, which captured the majority of known common variation within this gene region. PATIENTS: A dataset comprising 2504 UK Caucasian GD patients and 2784 geographically matched controls taken from the 1958 British Birth cohort. MEASUREMENTS: We used the chi(2)-test to investigate association between the Tag SNPs and GD. RESULTS: Association between the rs1801274 (P = 0.003, OR = 1.12 [95% CI = 1.03-1.22] and rs6427598 (P = 0.012, OR = 0.90 [95% CI = 0.83-0.98]) SNPs and GD was observed. No other SNPs showed association with GD. No associations were seen between any of the SNPs investigated and specific GD clinical phenotypes. CONCLUSIONS: This study suggests that variation in FcGRIIa predisposes to GD and further supports the role of FcGRIIa as a susceptibility locus for AIDs in general.
|
Authors | Kadija Yesmin, Chantal Hargreaves, Paul R Newby, Oliver J Brand, Joanne M Heward, Jayne A Franklyn, Stephen C L Gough, Matthew J Simmonds |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 73
Issue 1
Pg. 119-25
(Jul 2010)
ISSN: 1365-2265 [Electronic] England |
PMID | 20148910
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Autoantibodies
- Fc gamma receptor IIA
- Receptors, IgG
|
Topics |
- Autoantibodies
(metabolism)
- Case-Control Studies
- Disease Progression
- Genetic Predisposition to Disease
- Graves Disease
(genetics, immunology)
- Humans
- Middle Aged
- Polymorphism, Single Nucleotide
- Receptors, IgG
(genetics)
|